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The Respiratory System and Neuromuscular Diseases.

The more rapid pharmacodynamic effects of insulin lispro and insulin aspart make postabsorptive hypoglycemia less of a problem with these analogues than with regular insulin.

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Persons with type 2 diabetes may first be treated with oral medications, along with diet and exercise.

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Education about insulin physiology and the use of insulin in patients with diabetes should enable primary care providers to come closer to physiological insulin replacement and return glucose levels to near-normal concentrations.

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Weight reduction improves insulin sensitivity in cases of obesity and in most of the obesity-related insulin-resistant states.

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Less nocturnal hypoglycemia and better post-dinner glucose control with bedtime insulin glargine compared with bedtime NPH insulin during insulin combination therapy in type 2 diabetes.

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Johansen K, Ellegaard S, Wex S "Detection of nocturnal hypoglycemia in insulin-treated diabetics by a skin temperature-skin conductance meter.

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At the end of the study, which ran for a year, all the children were doing well, and in both groups, the mucosal lining of the small bowel (which is damaged by wheat gluten in celiac disease) had healed and the immune system (which is excessively reactive in celiac patients) had returned to normal.

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However, everyone benefits from becoming more aware of their dietary intake and matching their meals with appropriate insulin doses.

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In two small studies of people with either type 1 or type 2 diabetes, fenugreek seed powder lowered blood glucose and improved levels of blood cholesterol and triglycerides, among other beneficial effects.

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The IGT seen in the transgenic mice is explained by reduced tyrosine phosphorylation of IR and YXXM motif of IRS-1 in liver, which may be caused by indirect action given that IRS-1 protein levels were unchanged in liver ().

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One aspect alluded to but not discussed in detail are individualized effects of training on insulin sensitivity and MS factors.

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Broccoli and spinach measured 80 and 81, respectively; apple and banana measured 98 and 65; and of the whole grains tested, corn measured 181, whole wheat 77, oats 75, and brown rice 56.

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Type 1 diabetes was previously known as juvenile diabetes because it's usually diagnosed in children and young adults.

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Preliminary study of the effects of IGF-I treatment in insulin-dependent diabetes mellitus indicates that this hormone may have insulin-sparing effects; however, additional studies are needed to evaluate the effects of normalization of IGF-I levels on long-term metabolic control and diabetic complications.

This unusual condition may be caused in some people by the natural effects of insulin (one of which is to cause fat to grow) or by reuse of needles.

He or she will use this information to decide how much insulin is right for you.

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Initiate Insulin by Aggressive Titration and Education (INITIATE): a randomized study to compare initiation of insulin combination therapy in type 2 diabetic patients individually and in groups.

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Consider a twice-daily human mixed insulin regimen for adults with type 1 diabetes if an MDI basal-bolus insulin regimen is not possible and a twice-daily mixed insulin regimen is chosen.

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Both low blood sugar (hypoglycemia) and high blood sugar (hyperglycemia) are of concern for patients who take insulin.

Wolf JP, Massol J, Nguyen NU, Berthelay S "Arginine vasopressin response to insulin-induced hypoglycemia in insulin-dependent diabetics with asymptomatic hypoglycemia.

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She has essentially no beta-cell function and requires replacement therapy.

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Grab a fold of skin and inject the insulin at a 90-degree angle (PICTURE 3).

If changing from a treatment regimen with an intermediate- or long-acting insulin to a regimen with LANTUS, a change in the dose of the basal insulin may be required and the amount and timing of the shorter-acting insulins and doses of any oral anti-diabetic drugs may be needed to be adjusted.

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If you're thin, you may need to pinch the skin and inject the insulin at a 45-degree angle (PICTURE 4).

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Push the needle straight into the pinched-up skin at a 90-degree angle for an adult or at a 45-degree angle for a child.

Rapid-acting insulins should be given at the start of the meal.

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Neutral protamine Hagedorn insulin, better known as NPH insulin, is regular insulin combined with stoichiometric amounts of protamine, resulting in a poorly soluble insulin-protamine complex.

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Insulin pens are designed to be used multiple times, for a single person, using a new needle for each injection.

You might think of insulin resistance as similar to sitting in a smelly room and pretty soon you don't smell it anymore because you get desensitized.

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The solution: Once you have eliminated these variables, if the readings are still high, consider increasing the amount of your basal dose in consultation with your diabetes medical team.

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